Acute Wounds
Chronic Wounds
Dehisced Wounds
Diabetic Foot
Granulating/Epithelializing Wounds
Moderate/Highly Exudating Wounds
Pressure Ulcers
Superficial Wounds
Venous Ulcers

Preparation, Reconstitution and Surgical Use: Prior to implantation, carefully follow the EPIFIX® allograft preparation steps below using aseptic technique: Wound Bed Preparation Ensure the wound is free from clinical sign of infection. Prepare wound bed as needed. Removing EPIFIX® from Packaging The outer peel pouch is not sterile. The inner pouch that contains EPIFIX® is sterile (unless the pouches are damaged or compromised). Carefully open the peelable corner of the outer pouch and extract the inner pouch using aseptic technique. Ensure the inner pouch does not come in contact with any portions of non-sterile surface of the outer pouch. Using aseptic technique, slowly peel a corner of the inner peel pouch and allow the authorized medical professional to grasp EPIFIX® with fingers or non-toothed, sterile forceps. Use EPIFIX® promptly after opening the inner, sterile pouch. Please take great care when removing EPIFIX® from the internal pouch. EPIFIX® is thin and extremely lightweight. EPIFIX® Preparation In a dry state, use sterile dry scissors to cut EPIFIX® to fit within the wound margins. It is acceptable to overlap the wound margins with EPIFIX® by 1mm. If needed, EPIFIX® can be fenestrated to accommodate wounds that produce copious amounts of exudate. EPIFIX® can be applied wet or dry. EPIFIX® can be hydrated while on the wound site with sterile saline solution. Simply apply several drops of sterile solution to EPIFIX®. During and following hydration, the embossment on EPIFIX® will begin to fade. EPIFIX® Orientation & Application EPIFIX® should be placed on the wound site, using the orientation of the embossment lettering as a guide. Proper orientation of EPIFIX® can be noted when the embossment nomenclature reads correctly from left to right. Absorbable, non-absorbable suture material and/or tissue adhesives can be used to fixate EPIFIX® to the site of application or itself if desired. Support Therapies EPIFIX® is compatible with offloading/compression/negative pressure therapies. EPIFIX® can be used in conjunction with hyperbaric oxygen therapy.

Primary Dressing EPIFIX® should be covered with a non-adherent contact layer. EPIFIX® should not be disturbed, if possible, for several days or before the next application, if needed. If an infection occurs at the graft site, treat infection per institution’s protocol. Secondary Dressing EPIFIX® requires a moist wound environment. Use appropriate moisture management dressings for the wound type and treatment ideology.