MicroMatrix® Flex is the latest advancement in Integra's suite of wound management solutions which offers flexibility in treating complex and hard-to-reach wounds.
MicroMatrix Flex is powered by Integra’s proprietary Urinary Bladder Matrix (UBM) technology. This technology has been studied in over 200 clinical abstracts and publications and is proven to support rapid resorption in challenging microenvironments leading towards wound closure.1-15
This technology supports a shift in the inflammatory response by providing an environment where the body is more likely to exhibit a higher ratio of M2 to M1 macrophages.2,3 A lower M1:M2 ratio has been associated with site-appropriate tissue remodeling.3
MicroMatrix® Flex makes delivering UBM technology simpler with its innovative dual-syringe system even in the most difficult wound geometries, including:
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Irregular, deep or tunneled wounds
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Gravity-challenged areas (e.g., sacral region or foot)
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The flexible, bendable tip ensures precise application to promote healing even in challenging cases. This new system enhances the efficiency of UBM application.
A Proven Solution for Your Patients, MicroMatrix Flex combines proven, cutting-edge technology with elegant and practical device design, perfect for:
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Surgical wounds
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Pressure ulcers
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Diabetic ulcers
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Trauma wounds, and more.
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INDICATIONS
MicroMatrix Flex is intended for the management of wounds including: partial and full-thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, tunneled/undermined wounds, surgical wounds (donor sites/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence), trauma wounds (abrasions, lacerations, partial thickness burns, skin tears), draining wounds. The device is intended for one time use.
CONTRAINDICATIONS
1. Patients with known sensitivity or allergy to porcine materials.
2. Third-degree burns.
WARNINGS
1. If active infection is present, treat patient to resolve infection prior to device application.
2. Do not use if cracked, broken, or otherwise damaged.
3. MicroMatrix Flex device is not intended for the treatment of alopecia.
4. Do not connect the MicroMatrix Flex device to a hypodermic needle.
PRECAUTIONS
1. Always use aseptic technique when handling device.
2. Do not re-use.
3. Do not re-sterilize.
4. Do not cut dispensing tip
References:
1. LeCheminant J, Field C. Porcine urinary bladder matrix: a retrospective study and establishment of protocol. J Wound Care. 2012;21(10):476, 478-480, 482. 2. Paige JT, Kremer M, Landry J, et al. Modulation of inflammation in wounds of diabetic patients treated with porcine urinary bladder matrix. Regen Med. 2019;14(4):269-277. 3. Brown BN, Londono R, Tottey S, et al. Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials. Acta Biomater. 2012;8(3):978-987. 4. Valerio IL, Campbell P, Sabino J, Dearth CL, Fleming M. The use of urinary bladder matrix in the treatment of trauma and combat casualty wound care. Regen Med. 2015;10(5):611-622. 5. Kraemer BA, Geiger SE, Deigni OA, Watson JT. Management of open lower extremity wounds with concomitant fracture using a porcine urinary bladder matrix. Wounds. 2016;28(11):387-394. 6. Geiger SE, Deigni OA, Watson JT, Kraemer BA. Management of open distal lower extremity wounds with exposed tendons using porcine urinary bladder matrix. Wounds. 2016;28(9):306-316. 7. Brown B, Lindberg K, Reing J, Stolz DB, Badylak SF. The basement membrane component of biologic scaffolds derived from extracellular matrix. Tissue Eng. 2006;12(3):519-526. 8. Underwood P, Cardinal P, Keller E, et al. Extending limb salvage after fourth and fifth transmetatarsal amputation in diabetic foot infections using ACell® urinary bladder matrix. Am Surg. 2020;3134820973730. doi:10.1177/0003134820973730. 9. Lanier ST, Ruter DI, Valerio IL. Regenerative medicine for soft-tissue coverage of the hand and upper extremity. Curr Orthop Pract. 2018;29(2):120-126. 10. Sasse KC, Ackerman EM, Brandt JR. Complex wounds treated with MatriStem xenograft material: case series and cost analysis. OA Surgery. 2013;1(1):3. 11. Fokin AA, Puente I, Hus N, Rodriguez E, Weisz RD. Extracellular matrix applications in the treatment of open fractures with complex wounds and large soft tissue
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