How Biofilm and Prolonged Inflammation Affect the Wound Bed

Maintaining optimal wound bed conditions requires inflammation control and infection prevention. This includes preventing the formation of biofilms, which can delay healing. If biofilm prevention is not possible, wound care providers must optimize wound bed conditions to break the cycle of continuous inflammation and promote healing. This white paper begins with the TIMERS (tissue, inflammation, moisture, edge, repair or regeneration, and social factors) framework for wound bed preparation. It then describes the roles of biofilm in delayed wound healing and persistent inflammation and concludes with specific strategies for biofilm prevention and reduction.